We're cats, got a problem with that?

Nana, a cat, was created through genetic manipulation by a selfish man, endowed with human-like speech and intelligence. Nana was rescued by Suzu Kimura, director of the renowned Kimura Animal Hospital in Tokyo, after collapsing on Suzu's doorstep. Despite having lost some of her memories, Nana's unique abilities were put to use when she became an animal counselor.

Seven months after Nana and Suzu met, Nana married Tama, the pet cat of Suzu's cousin, Masami Hasegawa. They soon welcomed three kittens. While this was a joyous occasion, for some inexplicable reason, these three sisters were endowed with superpowers. Using these abilities, the three sisters interact with humans and animals, growing and developing along the way.